Smoking Intensity Increases Diaphragm Muscle Injury: A Clinicopathologic Study.

Nucci, Ricardo Aparecido Baptista; Busse, Alexandre Leopold; de Souza, Romeu Rodrigues; Maifrino, Laura Beatriz Mesiano; Pasqualucci, Carlos Augusto; Anaruma, Carlos Alberto; Leite, Renata Elaine Paraizo; Rodriguez, Roberta Diehl; Suemoto, Claudia Kimie; Jacob-Filho, Wilson

Nucci, Ricardo Aparecido Baptista; Busse, Alexandre Leopold; de Souza, Romeu Rodrigues; Maifrino, Laura Beatriz Mesiano; Pasqualucci, Carlos Augusto; Anaruma, Carlos Alberto; Leite, Renata Elaine Paraizo; Rodriguez, Roberta Diehl; Suemoto, Claudia Kimie; Jacob-Filho, Wilson.

Nucci RAB; Department of Pathology, Faculty of Medicine, University of São Paulo, São Paulo 01246-903, Brazil.
Busse AL; Laboratory of Medical Research in Aging (LIM-66), Division of Geriatrics, Faculty of Medicine, University of São Paulo, São Paulo 01246-903, Brazil.
de Souza RR; Department of Pathology, Faculty of Medicine, University of São Paulo, São Paulo 01246-903, Brazil.
Maifrino LBM; Laboratory of Medical Research in Aging (LIM-66), Division of Geriatrics, Faculty of Medicine, University of São Paulo, São Paulo 01246-903, Brazil.
Pasqualucci CA; Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.
Anaruma CA; Department of Anatomy, 9 de Julho University-UNINOVE, São Paulo 03155-000, Brazil.
Leite REP; Laboratory of Clinical Analysis, Faculty of Medicine of the ABC District, Santo André 09060-650, Brazil.
Rodriguez RD; Dante Pazzanese Institute of Cardiology, São Paulo 04012-909, Brazil.
Suemoto CK; Department of Pathology, Faculty of Medicine, University of São Paulo, São Paulo 01246-903, Brazil.
Jacob-Filho W; Laboratory of Morphology and Physical Activity, Department of Physical Education, São Paulo State University "Júlio de Mesquita Filho", Rio Claro 11330-900, Brazil.

J Clin Med ; 12(11)2023 Jun 02.

Article en En | MEDLINE | ID: mdl-37298016

ABSTRACT

ABSTRACT

BACKGROUND:

Studying the effects of smoking intensity is important to evaluate the risk of tobacco use on a range of illnesses, such as as sarcopenia among the elderly. Thus, this study aimed to analyze the effects of pack-years of cigarette smoking on the diaphragm muscle (DIAm) histopathology of postmortem samples.

METHODS:

Subjects were divided into three groups never-smoker (n = 46); less than 30 pack-years of smoking (n = 12); and more than 30 pack-years of smoking (n = 30). Diaphragm samples were stained with Picrosirius red and hematoxylin and eosin stain for general structure.

RESULTS:

Participants with more than 30 pack-years of cigarette smoking had a significant increase in adipocytes, blood vessels and collagen deposit, as well as an increase in histopathological alterations.