Novel Insights into the Pathophysiology and Treatment of Sickle Cell Disease.
Hemoglobin
; 47(2): 71-79, 2023 Nov.
Article
en En
| MEDLINE
| ID: mdl-37309063
ABSTRACT
The polymerization of hemoglobin under deoxygenation is the main pathophysiological event in sickle cell diseases, described more than 70 years ago. The last two decades have seen a major increase in knowledge about the cascade of events that follow the polymerization of hemoglobin and the ensuing sickling of red blood cells. Several distinctive therapeutic targets have been discovered as a result, and a few drugs with innovative mechanisms of action are already on the market, while several others are the focus of ongoing trials. The aim of this narrative review is to describe some of the more recent data in the SCD literature regarding pathophysiology and novel treatments.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hemoglobina Falciforme
/
Anemia de Células Falciformes
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article