Disrupting of family with sequence similarity 105, member A (Fam105a) deteriorates pancreatic ß-cell physiology and insulin secretion in INS-1 cells.

Taneera, Jalal; Khalique, Anila; Salima, Aissaoui; Mohammed, Abdul Khader; Sawan, Ahmed Saad; Aneis, Hamam; Habib, Peter; Abdrabh, Sham; Elemam, Noha M; Sharif-Askari, Narjes Saheb; Abu-Gharbieh, Eman; Saber-Ayad, Maha; El-Huneidi, Waseem

Disrupting of family with sequence similarity 105, member A (Fam105a) deteriorates pancreatic ß-cell physiology and insulin secretion in INS-1 cells.

Taneera, Jalal; Khalique, Anila; Salima, Aissaoui; Mohammed, Abdul Khader; Sawan, Ahmed Saad; Aneis, Hamam; Habib, Peter; Abdrabh, Sham; Elemam, Noha M; Sharif-Askari, Narjes Saheb; Abu-Gharbieh, Eman; Saber-Ayad, Maha; El-Huneidi, Waseem.

Taneera J; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. Electronic address: jtaneera@sharjah.ac.ae.
Khalique A; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Salima A; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; Laboratory of Molecular Toxicology, Faculty of Nature and Life Sciences, University of Mohammed Seddik Benyahia-Jijel, Jijel, Algeria.
Mohammed AK; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Sawan AS; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Aneis H; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Habib P; School of Information Technology and Computer Science (ITCS), Nile University, Giza, Egypt.
Abdrabh S; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Elemam NM; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Sharif-Askari NS; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Abu-Gharbieh E; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Saber-Ayad M; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
El-Huneidi W; College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.

Mol Cell Endocrinol ; 574: 111987, 2023 08 20.

Article en En | MEDLINE | ID: mdl-37311518

Asunto(s)

Diabetes Mellitus Tipo 2; Células Secretoras de Insulina; Islotes Pancreáticos; Humanos; Secreción de Insulina; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/metabolismo; Células Secretoras de Insulina/metabolismo; Insulina/metabolismo; Supervivencia Celular/genética; Glucosa/metabolismo; Islotes Pancreáticos/metabolismo

Palabras clave

FAM105A; Glucose uptake; Human islets; INS-1 cells; Insulin secretion; RNA-seq; Type 2 diabetes; siRNA

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Islotes Pancreáticos / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article

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