New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle.
Mar Drugs
; 21(6)2023 Jun 16.
Article
en En
| MEDLINE
| ID: mdl-37367687
ABSTRACT
Fifteen new diterpenoids, namely xishaklyanes A-O (1-15), along with three known related ones (16-18), were isolated from the soft coral Klyxum molle collected from Xisha Islands, South China Sea. The stereochemistry of the new compounds was elucidated by a combination of detailed spectroscopic analyses, chemical derivatization, quantum chemical calculations, and comparison with the reported data. The absolute configuration of compound 18 was established by the modified Mosher's method for the first time. In bioassay, some of these compounds exhibited considerable antibacterial activities on fish pathogenic bacteria, and compound 4 showed the most effective activity with MIC of 0.225 µg/mL against Lactococcus garvieae.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antozoos
/
Diterpenos
Límite:
Animals
País como asunto:
Asia
Idioma:
En
Año:
2023
Tipo del documento:
Article