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Two-Year Duration of Immunity of Inactivated Poliovirus Vaccine: A Follow-up Study in Pakistan in 2020.
Saleem, Ali Faisal; Parkar, Sadia; Zehra, Syeda Mahjabeen; Kazi, Zaubina; Pethani, Asma; Zhang, Yiting; Mainou, Bernardo A; Cavestany, Rocio Lopez; Macklin, Grace; Jeyaseelan, Visalakshi; Mach, Ondrej.
  • Saleem AF; Department of Paediatrics and Child Health, Aga Khan University Karachi, Pakistan.
  • Parkar S; Department of Paediatrics and Child Health, Aga Khan University Karachi, Pakistan.
  • Zehra SM; Department of Paediatrics and Child Health, Aga Khan University Karachi, Pakistan.
  • Kazi Z; Department of Paediatrics and Child Health, Aga Khan University Karachi, Pakistan.
  • Pethani A; Department of Paediatrics and Child Health, Aga Khan University Karachi, Pakistan.
  • Zhang Y; Population Immunity Laboratory, Polio and Picornavirus Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA.
  • Mainou BA; Population Immunity Laboratory, Polio and Picornavirus Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA.
  • Cavestany RL; Polio Eradication, World Health Organization Geneva, Switzerland.
  • Macklin G; Polio Eradication, World Health Organization Geneva, Switzerland.
  • Jeyaseelan V; Polio Eradication, World Health Organization Geneva, Switzerland.
  • Mach O; Polio Eradication, World Health Organization Geneva, Switzerland.
J Infect Dis ; 229(1): 39-42, 2024 Jan 12.
Article en En | MEDLINE | ID: mdl-37368349
ABSTRACT
This was a follow-up study conducted in 2020 assessing changes in levels of type 2 poliovirus-neutralizing antibodies 2 years postimmunization in children who received inactivated poliovirus vaccine (IPV) in Karachi, Pakistan. Unexpectedly, the findings revealed an increase in seroprevalence of type 2 antibodies from 73.1% to 81.6% 1 year and 2 years after IPV, respectively. The increase in type 2 immunity could result from the intensive transmission of circulating vaccine-derived poliovirus type 2 (cVDPV2) in Karachi during the second year of IPV administration. This study suggests that the cVDPV2 outbreak detected in Pakistan infected large proportions of children in Karachi. Clinical Trials Registration . NCT03286803.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Poliomielitis / Poliovirus Tipo de estudio: Observational_studies / Prognostic_studies Límite: Child / Humans País como asunto: Asia Idioma: En Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Poliomielitis / Poliovirus Tipo de estudio: Observational_studies / Prognostic_studies Límite: Child / Humans País como asunto: Asia Idioma: En Año: 2024 Tipo del documento: Article