Novel Cerium(IV) Coordination Compounds of Monensin and Salinomycin.
Molecules
; 28(12)2023 Jun 09.
Article
en En
| MEDLINE
| ID: mdl-37375231
ABSTRACT
The largely uncharted complexation chemistry of the veterinary polyether ionophores, monensic and salinomycinic acids (HL) with metal ions of type M4+ and the known antiproliferative potential of antibiotics has provoked our interest in exploring the coordination processes between MonH/SalH and ions of Ce4+. (1) Methods:
Novel monensinate and salinomycinate cerium(IV)-based complexes were synthesized and structurally characterized by elemental analysis, a plethora of physicochemical methods, density functional theory, molecular dynamics, and biological assays. (2)Results:
The formation of coordination species of a general composition [CeL2(OH)2] and [CeL(NO3)2(OH)], depending on reaction conditions, was proven both experimentally and theoretically. The metal(IV) complexes [CeL(NO3)2(OH)] possess promising cytotoxic activity against the human tumor uterine cervix (HeLa) cell line, being highly selective (non-tumor embryo Lep-3 vs. HeLa) compared to cisplatin, oxaliplatin, and epirubicin.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Monensina
/
Cerio
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article