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Superspreading of SARS-CoV-2 Omicron BA.2.23 among vaccinated Finnish adults: symptomatic COVID-19 only contracted by those without recent infection.
Riekkinen, Marianna; Kajova, Mikael; Eriksson, Mari; Luukkainen, Annika; Holmberg, Ville; Aro, Tuomas; Pakkanen, Sari H; Miettinen, Simo; Montonen, Reetta; Smura, Teemu; Lääveri, Tinja; Kantele, Anu.
  • Riekkinen M; Department of Infectious Diseases, Inflammation Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
  • Kajova M; Human Microbiome Research Unit, University of Helsinki, Helsinki, Finland.
  • Eriksson M; Meilahti Vaccine Research Centre, MeVac, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Luukkainen A; Department of Infectious Diseases, Inflammation Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
  • Holmberg V; Human Microbiome Research Unit, University of Helsinki, Helsinki, Finland.
  • Aro T; Meilahti Vaccine Research Centre, MeVac, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Pakkanen SH; Department of Infectious Diseases, Inflammation Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
  • Miettinen S; Department of Infectious Diseases, Inflammation Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
  • Montonen R; Department of Infectious Diseases, Inflammation Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
  • Smura T; Human Microbiome Research Unit, University of Helsinki, Helsinki, Finland.
  • Lääveri T; Department of Infectious Diseases, Inflammation Centre, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
  • Kantele A; Human Microbiome Research Unit, University of Helsinki, Helsinki, Finland.
Epidemiol Infect ; 151: e113, 2023 07 04.
Article en En | MEDLINE | ID: mdl-37401478
ABSTRACT
An outbreak of SARS-CoV-2 was confirmed after an academic party in Helsinki, Finland, in 2022. All 70 guests were requested to fill in follow-up questionnaires; serologic analyses and whole-genome sequencing (WGS) were conducted when possible.Of those participating - all but one with ≥3 vaccine doses - 21/53 (40%) had test-confirmed symptomatic COVID-19 7% of those with earlier episodes and 76% of those without. Half (11/21) were febrile, but none needed hospitalisation. WGS revealed subvariant BA.2.23.Compared to vaccination alone, our data suggest remarkable protection by hybrid immunity against symptomatic infection, particularly in instances of recent infections with homologous variants.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Diagnostic_studies Límite: Humans País como asunto: Europa Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Diagnostic_studies Límite: Humans País como asunto: Europa Idioma: En Año: 2023 Tipo del documento: Article