Glycyrrhiza polysaccharides inhibits PRRSV replication.
Virol J
; 20(1): 140, 2023 07 05.
Article
en En
| MEDLINE
| ID: mdl-37408066
ABSTRACT
Glycyrrhiza polysaccharide (GCP) is a natural plant active polysaccharide extracted from traditional Chinese medicine licorice. In this research, we studied the antiviral activity of glycyrrhiza polysaccharide against porcine reproductive and respiratory syndrome virus (PRRSV), a virus of the Arteriviridae family, with a high rate of variation and has caused huge economic losses to the pig industry in various countries since its discovery. Our results show that GCP can inhibit PRRSV replication in a dose-dependent manner. Furthermore, GCP could inhibit the mRNA expression of receptor genes CD163 and NF-κB p65 and promote the mRNA expression of the SLA-7 gene. Because of these results, GCP can be used as a candidate drug to prevent and treat PRRS.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Virus del Síndrome Respiratorio y Reproductivo Porcino
/
Síndrome Respiratorio y de la Reproducción Porcina
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Glycyrrhiza
Límite:
Animals
Idioma:
En
Año:
2023
Tipo del documento:
Article