Development and validation of HPLC method for simultaneous determination of Leflunomide and folic acid in the nanoparticulate system by reversed-phase HPLC.
Drug Dev Ind Pharm
; 49(8): 497-507, 2023 Aug.
Article
en En
| MEDLINE
| ID: mdl-37470519
HighlightsOptimization and validation of the RP-HPLC method were performed for the simultaneous detection of LEF and FA.Validation was performed on the basis of linearity, accuracy, precision, LOD, LOQ, and robustness in accordance with ICH criteria.Validated analytical procedure was employed for the simultaneous detection of LEF and FA from polymeric nanocarriers.The proposed analytical method is reliable, fast, robust, and can be successfully applied for quantification of % EE, and % DL in polymeric nanocarriers.
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MEDLINE
Asunto principal:
Polímeros
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Ácido Fólico
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En
Año:
2023
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Article