Salivary secretory immunoglobulin A as a potential biomarker of psychosocial stress response during the first stages of life: A systematic review.
Front Neuroendocrinol
; 71: 101083, 2023 10.
Article
en En
| MEDLINE
| ID: mdl-37479062
ABSTRACT
Mucosal secretory immunoglobulin A (s-IgA) has been recognized as a key component of human first line defense against infection. However, its reactivity to psychosocial stressors is poorly understood. This systematic review aimed to explore whether s-IgA levels changed after psychosocial stress in subjects under the age of 18. Fifteen articles were included. s-IgA basal levels are increased in children older than 9 years old exposed to stress. Furthermore, s-IgA seems to follow a circadian rhythm, which is altered under stress conditions. Finally, the collective evidence suggests that salivary s-IgA rapidly increases under acute stress after puberty. Overall, our review indicates that s-IgA could be considered a potential psychosocial stress biomarker of interest for pediatric and child-juvenile psychiatric population. Further studies are needed to validate the role of s-IgA circadian rhythm and basal levels as psychosocial stress biomarkers and disentangle the role of age and type of stressor.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Saliva
/
Inmunoglobulina A Secretora
Tipo de estudio:
Systematic_reviews
Límite:
Child
/
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article