Efficacy of KPR-5714, a selective transient receptor potential melastatin 8 antagonist, on chronic psychological stress-induced bladder overactivity in male rats.
Neurourol Urodyn
; 42(8): 1812-1821, 2023 Nov.
Article
en En
| MEDLINE
| ID: mdl-37498134
ABSTRACT
AIMS:
Chronic psychological stress aggravates lower urinary tract symptoms. Among others, water avoidance stress is a chronic psychological stressor that plays a causal role in the exacerbation and development of bladder dysfunction in rats. In this report, the effects of KPR-5714, which is a selective transient receptor potential melastatin 8 (TRPM8) antagonist, on bladder overactivity induced by water avoidance stress were examined.METHODS:
Male rats were subjected to water avoidance stress for 2 h per day for 10 consecutive days. The effects of water avoidance stress on voiding behavior using metabolic cages and histological bladder changes were investigated in rats. The involvement of bladder C-fiber afferent on voiding frequency in rats exposed to water avoidance stress was assessed using capsaicin. The effects of KPR-5714 on storage dysfunction in rats subjected to water avoidance stress were examined.RESULTS:
In voiding behavior measurements, water avoidance stress-induced storage dysfunction, causing a decrease in the mean voided volume and increasing voiding frequency. A comparison of bladders from normal rats and rats exposed to water avoidance stress showed no histological differences. Water avoidance stress-induced bladder overactivity was completely inhibited by pretreatment with capsaicin. KPR-5714 showed a tendency to increase the mean voided volume and significantly decreased the voiding frequency without affecting the total voided volume in these rats.CONCLUSION:
The results suggest that KPR-5714 is a promising option for treating chronic psychological stress-induced bladder overactivity.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vejiga Urinaria
/
Vejiga Urinaria Hiperactiva
Límite:
Animals
Idioma:
En
Año:
2023
Tipo del documento:
Article