Cycloaddition of N-arylnitrones with donor-acceptor oxiranes via C-C bond cleavage to construct 1,5,2-dioxazinanes.
Org Biomol Chem
; 21(33): 6778-6782, 2023 Aug 23.
Article
en En
| MEDLINE
| ID: mdl-37564027
ABSTRACT
Highly functionalized 1,5,2-dioxazinanes could be smoothly produced via a Sc(OTf)3-catalyzed chemoselective [3 + 3] cycloaddition of various N-arylnitrones with a series of donor-acceptor oxiranes. This reaction involves in situ generation of 1,3-dipoles through Sc(OTf)3-catalyzed C-C bond cleavage of oxiranes and moderate to high yields were obtained for most substrates. This transformation features C-C bond cleavage of donor-acceptor oxiranes, accessible starting materials and mild reaction conditions.
Texto completo:
1
Banco de datos:
MEDLINE
Idioma:
En
Año:
2023
Tipo del documento:
Article