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Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.
Kanis, J A; Johansson, H; McCloskey, E V; Liu, E; Åkesson, K E; Anderson, F A; Azagra, R; Bager, C L; Beaudart, C; Bischoff-Ferrari, H A; Biver, E; Bruyère, O; Cauley, J A; Center, J R; Chapurlat, R; Christiansen, C; Cooper, C; Crandall, C J; Cummings, S R; da Silva, J A P; Dawson-Hughes, B; Diez-Perez, A; Dufour, A B; Eisman, J A; Elders, P J M; Ferrari, S; Fujita, Y; Fujiwara, S; Glüer, C-C; Goldshtein, I; Goltzman, D; Gudnason, V; Hall, J; Hans, D; Hoff, M; Hollick, R J; Huisman, M; Iki, M; Ish-Shalom, S; Jones, G; Karlsson, M K; Khosla, S; Kiel, D P; Koh, W-P; Koromani, F; Kotowicz, M A; Kröger, H; Kwok, T; Lamy, O; Langhammer, A.
  • Kanis JA; Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia. w.j.Pontefract@sheffield.ac.uk.
  • Johansson H; Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK. w.j.Pontefract@sheffield.ac.uk.
  • McCloskey EV; Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
  • Liu E; Sahlgrenska Osteoporosis Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
  • Åkesson KE; Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.
  • Anderson FA; MRC Versus Arthritis Centre for Integrated research in Musculoskeletal Ageing, Mellanby Centre for Musculoskeletal Research, University of Sheffield, Sheffield, UK.
  • Azagra R; Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
  • Bager CL; Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden.
  • Beaudart C; Department of Orthopedics, Skåne University Hospital, Malmö, Sweden.
  • Bischoff-Ferrari HA; GLOW Coordinating Center, Center for Outcomes Research, University of Massachusetts Medical School, Worcester, MA, USA.
  • Biver E; Department of Medicine, Autonomous University of Barcelona, Barcelona, Spain.
  • Bruyère O; Health Centre Badia del Valles, Catalan Institute of Health, Barcelona, Spain.
  • Cauley JA; PRECIOSA-Fundación para la investigación, Barberà del Vallés, Barcelona, Spain.
  • Center JR; Nordic Bioscience A/S, Herlev, Denmark.
  • Chapurlat R; WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.
  • Christiansen C; Department of Health Services Research, University of Maastricht, Maastricht, the Netherlands.
  • Cooper C; Department of Aging Medicine and Aging Research, University Hospital, Zurich, and University of Zurich, Zurich, Switzerland.
  • Crandall CJ; Centre on Aging and Mobility, University of Zurich and City Hospital, Zurich, Switzerland.
  • Cummings SR; Division of Bone Diseases, Department of Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • da Silva JAP; WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Division of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium.
  • Dawson-Hughes B; Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Philadelphia, USA.
  • Diez-Perez A; Skeletal Diseases Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.
  • Dufour AB; St Vincent's Clinical School, School of Medicine and Health, University of New South Wales Sydney, Sydney, NSW, Australia.
  • Eisman JA; School of Medicine Sydney, University of Notre Dame Australia, Sydney, NSW, Australia.
  • Elders PJM; INSERM UMR 1033, Université Claude Bernard-Lyon1, Hôpital Edouard Herriot, Lyon, France.
  • Ferrari S; Nordic Bioscience A/S, Herlev, Denmark.
  • Fujita Y; MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK.
  • Fujiwara S; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospitals Southampton NHS Foundation Trust, Southampton, UK.
  • Glüer CC; NIHR Oxford Biomedical Research Unit, University of Oxford, Oxford, UK.
  • Goldshtein I; Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
  • Goltzman D; San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA.
  • Gudnason V; Coimbra Institute for Clinical and Biomedical Research, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
  • Hall J; Rheumatology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
  • Hans D; Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
  • Hoff M; Department of Internal Medicine, Hospital del Mar and CIBERFES, Autonomous University of Barcelona, Barcelona, Spain.
  • Hollick RJ; Marcus Institute for Aging Research, Hebrew Senior Life, Boston, MA, USA.
  • Huisman M; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
  • Iki M; Skeletal Diseases Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.
  • Ish-Shalom S; St Vincent's Clinical School, School of Medicine and Health, University of New South Wales Sydney, Sydney, NSW, Australia.
  • Jones G; School of Medicine Sydney, University of Notre Dame Australia, Sydney, NSW, Australia.
  • Karlsson MK; Petra JM Elders Department of General Practice, Amsterdam UMC, location AMC, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
  • Khosla S; Division of Bone Diseases, Department of Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Kiel DP; Center for Medical Education and Clinical Training, Kindai University Faculty of Medicine, Osaka, Japan.
  • Koh WP; Department of Pharmacy, Yasuda Women's University, Hiroshima, Japan.
  • Koromani F; Section Biomedical Imaging, Molecular Imaging North Competence Center, Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein Kiel, Kiel University, Kiel, Germany.
  • Kotowicz MA; Maccabitech Institute of Research and Innovation, Maccabi Healthcare Services, Tel Aviv, Israel.
  • Kröger H; Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Kwok T; Department of Medicine, McGill University and McGill University Health Centre, Montreal, Canada.
  • Lamy O; Icelandic Heart Association, Kopavogur, Iceland.
  • Langhammer A; University of Iceland, Reykjavik, Iceland.
Osteoporos Int ; 34(12): 2027-2045, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37566158
ABSTRACT
A large international meta-analysis using primary data from 64 cohorts has quantified the increased risk of fracture associated with a previous history of fracture for future use in FRAX.

INTRODUCTION:

The aim of this study was to quantify the fracture risk associated with a prior fracture on an international basis and to explore the relationship of this risk with age, sex, time since baseline and bone mineral density (BMD).

METHODS:

We studied 665,971 men and 1,438,535 women from 64 cohorts in 32 countries followed for a total of 19.5 million person-years. The effect of a prior history of fracture on the risk of any clinical fracture, any osteoporotic fracture, major osteoporotic fracture, and hip fracture alone was examined using an extended Poisson model in each cohort. Covariates examined were age, sex, BMD, and duration of follow-up. The results of the different studies were merged by using the weighted ß-coefficients.

RESULTS:

A previous fracture history, compared with individuals without a prior fracture, was associated with a significantly increased risk of any clinical fracture (hazard ratio, HR = 1.88; 95% CI = 1.72-2.07). The risk ratio was similar for the outcome of osteoporotic fracture (HR = 1.87; 95% CI = 1.69-2.07), major osteoporotic fracture (HR = 1.83; 95% CI = 1.63-2.06), or for hip fracture (HR = 1.82; 95% CI = 1.62-2.06). There was no significant difference in risk ratio between men and women. Subsequent fracture risk was marginally downward adjusted when account was taken of BMD. Low BMD explained a minority of the risk for any clinical fracture (14%), osteoporotic fracture (17%), and for hip fracture (33%). The risk ratio for all fracture outcomes related to prior fracture decreased significantly with adjustment for age and time since baseline examination.

CONCLUSION:

A previous history of fracture confers an increased risk of fracture of substantial importance beyond that explained by BMD. The effect is similar in men and women. Its quantitation on an international basis permits the more accurate use of this risk factor in case finding strategies.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Osteoporosis / Fracturas Osteoporóticas / Fracturas de Cadera Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans / Male Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Osteoporosis / Fracturas Osteoporóticas / Fracturas de Cadera Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans / Male Idioma: En Año: 2023 Tipo del documento: Article