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Thyroid Hormone Regulates the Lipid Content of Muscle Fibers, Thus Affecting Physical Exercise Performance.
Miro, Caterina; Nappi, Annarita; Sagliocchi, Serena; Di Cicco, Emery; Murolo, Melania; Torabinejad, Sepehr; Acampora, Lucia; Pastore, Arianna; Luciano, Paolo; La Civita, Evelina; Terracciano, Daniela; Stornaiuolo, Mariano; Dentice, Monica; Cicatiello, Annunziata Gaetana.
  • Miro C; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.
  • Nappi A; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.
  • Sagliocchi S; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.
  • Di Cicco E; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.
  • Murolo M; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.
  • Torabinejad S; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.
  • Acampora L; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.
  • Pastore A; Department of Pharmacy, University of Naples "Federico II", 80149 Naples, Italy.
  • Luciano P; Department of Pharmacy, University of Naples "Federico II", 80149 Naples, Italy.
  • La Civita E; Department of Translational Medical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
  • Terracciano D; Department of Translational Medical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
  • Stornaiuolo M; Department of Pharmacy, University of Naples "Federico II", 80149 Naples, Italy.
  • Dentice M; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy.
  • Cicatiello AG; CEINGE-Biotecnologie Avanzate S.c.a.r.l., 80131 Naples, Italy.
Int J Mol Sci ; 24(15)2023 Jul 28.
Article en En | MEDLINE | ID: mdl-37569453
ABSTRACT
Skeletal muscle (SkM) lipid composition plays an essential role in physiological muscle maintenance and exercise performance. Thyroid hormones (THs) regulate muscle formation and fuel energy utilization by modulating carbohydrates and lipid and protein metabolism. The best-known effects of THs in SkM include the promotion of mitochondrial biogenesis, the fiber-type switch from oxidative to glycolytic fibers, and enhanced angiogenesis. To assess the role of THs on the lipidic composition of SkM fibers, we performed lipidomic analyses of SkM cells and tissues, glucose tolerance experiments, and exercise performance tests. Our data demonstrated that TH treatment induces remodeling of the lipid profile and changes the proportion of fatty acids in SkM. In brief, THs significantly reduced the ratio of stearic/oleic acid in the muscle similar to what is induced by physical activity. The increased proportion of unsaturated fatty acids was linked to an improvement in insulin sensitivity and endurance exercise. These findings point to THs as critical endocrine factors affecting exercise performance and indicate that homeostatic maintenance of TH signals, by improving cell permeability and receptor stability at the cell membrane, is crucial for muscle physiology.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Músculo Esquelético / Fibras Musculares Esqueléticas Idioma: En Año: 2023 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Músculo Esquelético / Fibras Musculares Esqueléticas Idioma: En Año: 2023 Tipo del documento: Article