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Mouse phenome database: curated data repository with interactive multi-population and multi-trait analyses.
Bogue, Molly A; Ball, Robyn L; Walton, David O; Dunn, Matthew H; Kolishovski, Georgi; Berger, Alexander; Lamoureux, Anna; Grubb, Stephen C; Gerring, Matthew; Kim, Matthew; Liang, Hongping; Emerson, Jake; Stearns, Timothy; He, Hao; Mukherjee, Gaurab; Bluis, John; Davis, Sara; Desai, Sejal; Sundberg, Beth; Kadakkuzha, Beena; Kunde-Ramamoorthy, Govindarajan; Philip, Vivek M; Chesler, Elissa J.
  • Bogue MA; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA. Molly.Bogue@jax.org.
  • Ball RL; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Walton DO; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Dunn MH; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Kolishovski G; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Berger A; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Lamoureux A; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Grubb SC; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Gerring M; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Kim M; University of British Columbia, Vancouver, BC, Canada.
  • Liang H; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Emerson J; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Stearns T; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • He H; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Mukherjee G; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Bluis J; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Davis S; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Desai S; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Sundberg B; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Kadakkuzha B; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Kunde-Ramamoorthy G; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Philip VM; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
  • Chesler EJ; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, USA.
Mamm Genome ; 34(4): 509-519, 2023 12.
Article en En | MEDLINE | ID: mdl-37581698
ABSTRACT
The Mouse Phenome Database continues to serve as a curated repository and analysis suite for measured attributes of members of diverse mouse populations. The repository includes annotation to community standard ontologies and guidelines, a database of allelic states for 657 mouse strains, a collection of protocols, and analysis tools for flexible, interactive, user directed analyses that increasingly integrates data across traits and populations. The database has grown from its initial focus on a standard set of inbred strains to include heterogeneous mouse populations such as the Diversity Outbred and mapping crosses and well as Collaborative Cross, Hybrid Mouse Diversity Panel, and recombinant inbred strains. Most recently the system has expanded to include data from the International Mouse Phenotyping Consortium. Collectively these data are accessible by API and provided with an interactive tool suite that enables users' persistent selection, storage, and operation on collections of measures. The tool suite allows basic analyses, advanced functions with dynamic visualization including multi-population meta-analysis, multivariate outlier detection, trait pattern matching, correlation analyses and other functions. The data resources and analysis suite provide users a flexible environment in which to explore the basis of phenotypic variation in health and disease across the lifespan.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fenómica Tipo de estudio: Systematic_reviews Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fenómica Tipo de estudio: Systematic_reviews Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article