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Tissue Biology: In Search of a New Paradigm.
Adler, Miri; Chavan, Arun R; Medzhitov, Ruslan.
  • Adler M; Tananbaum Center for Theoretical and Analytical Human Biology, Yale University School of Medicine, New Haven, Connecticut, USA; email: ruslan.medzhitov@yale.edu.
  • Chavan AR; Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Medzhitov R; Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Annu Rev Cell Dev Biol ; 39: 67-89, 2023 10 16.
Article en En | MEDLINE | ID: mdl-37607470
ABSTRACT
Animal tissues are made up of multiple cell types that are increasingly well-characterized, yet our understanding of the core principles that govern tissue organization is still incomplete. This is in part because many observable tissue characteristics, such as cellular composition and spatial patterns, are emergent properties, and as such, they cannot be explained through the knowledge of individual cells alone. Here we propose a complex systems theory perspective to address this fundamental gap in our understanding of tissue biology. We introduce the concept of cell categories, which is based on cell relations rather than cell identity. Based on these notions we then discuss common principles of tissue modularity, introducing compositional, structural, and functional tissue modules. Cell diversity and cell relations provide a basis for a new perspective on the underlying principles of tissue organization in health and disease.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biología Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biología Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article