Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study.

Bällgren, Frida; Hammarlund-Udenaes, Margareta; Loryan, Irena

Bällgren, Frida; Hammarlund-Udenaes, Margareta; Loryan, Irena.

Bällgren F; Translational Pharmacokinetics/Pharmacodynamics group (tPKPD), Department of Pharmacy, Uppsala University, Box 580, 75123, Uppsala, Sweden. frida.ballgren@farmaci.uu.se.
Hammarlund-Udenaes M; Translational Pharmacokinetics/Pharmacodynamics group (tPKPD), Department of Pharmacy, Uppsala University, Box 580, 75123, Uppsala, Sweden.
Loryan I; Translational Pharmacokinetics/Pharmacodynamics group (tPKPD), Department of Pharmacy, Uppsala University, Box 580, 75123, Uppsala, Sweden. irena.loryan@farmaci.uu.se.

Pharm Res ; 40(11): 2715-2730, 2023 Nov.

Article en En | MEDLINE | ID: mdl-37610619

Asunto(s)

Barrera Hematoencefálica; Oxicodona; Ratas; Femenino; Masculino; Animales; Oxicodona/farmacocinética; Microdiálisis; Caracteres Sexuales; Ratas Sprague-Dawley; Encéfalo; Antiportadores

Palabras clave

blood-brain barrier; blood-cerebrospinal fluid barrier; brain interstitial fluid; cerebrospinal fluid; microdialysis; oxycodone; proton-coupled organic cation (H+/OC) antiporter; rat; sex

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxicodona / Barrera Hematoencefálica Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxicodona / Barrera Hematoencefálica Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article