Autoantibodies to acetylcholine receptor in myasthenia gravis: light chains.
Neurology
; 36(11): 1531-3, 1986 Nov.
Article
en En
| MEDLINE
| ID: mdl-3762974
ABSTRACT
We studied the light chain type of autoantibodies to acetylcholine receptor (AChR) by affinity chromatography with monoclonal anti-kappa and anti-lambda antibodies. The autoantibodies in four of eight myasthenic patients were of a single light chain type; the others comprised both types. In Graves' disease and cold-reactive hemolytic anemia, the pathogenic autoantibodies are confined to a single light chain type in individual patients, and in other diseases, doubtfully pathogenic autoantibodies are invariably mixtures of both light chain types. AChR antibodies may comprise both pathogenic and nonpathogenic types of autoantibody.
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Banco de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Receptores Colinérgicos
/
Miastenia Gravis
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1986
Tipo del documento:
Article