Your browser doesn't support javascript.
loading
A Toxoplasma gondii lipoxygenase-like enzyme is necessary for virulence and changes localization associated with the host immune response.
Ramírez-Flores, Carlos J; Erazo Flores, Billy Joel; Tibabuzo Perdomo, Andrés M; Barnes, Katie L; Wilson, Sarah K; Mendoza Cavazos, Carolina; Knoll, Laura J.
  • Ramírez-Flores CJ; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Erazo Flores BJ; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Tibabuzo Perdomo AM; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Barnes KL; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Wilson SK; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Mendoza Cavazos C; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Knoll LJ; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison , Madison, Wisconsin, USA.
mBio ; 14(5): e0127923, 2023 Oct 31.
Article en En | MEDLINE | ID: mdl-37646522
ABSTRACT
IMPORTANCE Lipoxygenases (LOXs) are enzymes that catalyze the deoxygenation of polyunsaturated fatty acids such as linoleic and arachidonic acid. These modifications create signaling molecules that are best characterized for modulating the immune response. Deletion of the first lipoxygenase-like enzyme characterized for Toxoplasma gondii (TgLOXL1) generated a less virulent strain, and infected mice showed a decreased immune response. This virulence defect was dependent on the mouse cytokine interferon gamma IFNγ. TgLOXL1 changes location from inside the parasite in tissue culture conditions to vesicular structures within the host immune cells during mouse infection. These results suggest that TgLOXL1 plays a role in the modification of the host immune response in mice.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Toxoplasma Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Toxoplasma Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article