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Males with sickle cell disease have higher risks of cerebrovascular disease, increased inflammation, and a reduced response to hydroxyurea.
Di Mauro, Margherita; El Hoss, Sara; Nardo-Marino, Amina; Stuart-Smith, Sara; Strouboulis, John; Gibson, John S; Rees, David C; Brewin, John N.
  • Di Mauro M; Department of Haematological Medicine, King's College Hospital, London, UK.
  • El Hoss S; Red Cell Haematology Laboratory, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
  • Nardo-Marino A; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Stuart-Smith S; Red Cell Haematology Laboratory, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
  • Strouboulis J; Department of Haematological Medicine, King's College Hospital, London, UK.
  • Gibson JS; Red Cell Haematology Laboratory, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
  • Rees DC; Centre for Haemoglobinopathies, Department of Haematology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
  • Brewin JN; Department of Haematological Medicine, King's College Hospital, London, UK.
Am J Hematol ; 98(11): E341-E344, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37646569
ABSTRACT
Biological sex is important. Male sex is associated with worse outcomes in most measures, including cerebrovascular disease, hospital admissions, and blood transfusions, but not survival. Females also appear to have a better response to hydroxyurea therapy, reduced markers of inflammation, and better liver function.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastornos Cerebrovasculares / Anemia de Células Falciformes Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastornos Cerebrovasculares / Anemia de Células Falciformes Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Año: 2023 Tipo del documento: Article