PD-1 negatively tunes macrophage immune activation by turning off JNK and STAT1 signaling: Exploited by Leishmania for its intra-macrophage survival.

Roy, Shalini; Gupta, Anand K; Banerjee, Madhurima; Das, Pijush K; Ukil, Anindita.

Roy S; CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700032, India.
Gupta AK; CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700032, India.
Banerjee M; Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, India.
Das PK; CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700032, India. Electronic address: pijush52@gmail.com.
Ukil A; Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Road, Kolkata 700019, India. Electronic address: u.anindita@gmail.com.

Cell Immunol ; 391-392: 104758, 2023.

Article en En | MEDLINE | ID: mdl-37651886

Asunto(s)

Leishmania; Receptor de Muerte Celular Programada 1; Línea Celular; Macrófagos; Fosforilación; Factores de Transcripción/metabolismo; Antiinflamatorios; Proteínas Quinasas JNK Activadas por Mitógenos; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo

Palabras clave

JNK; Leishmania; PD-1; STAT1; cytokine; macrophage