Investigation of Simultaneous and Sequential Cooperative Homotropic Inhibitor Binding to the Catalytic Chamber of SARS-CoV-2 RNA-dependent RNA Polymerase (RdRp).

Metwally, Kamel; Abo-Dya, Nader E; Hamdan, Ahmed M E; Alrashidi, Maram N; Alturki, Mansour S; Aly, Omar M; Aljoundi, Aimen; Ibrahim, Mahmoud; Soliman, Mahmoud E S

Metwally, Kamel; Abo-Dya, Nader E; Hamdan, Ahmed M E; Alrashidi, Maram N; Alturki, Mansour S; Aly, Omar M; Aljoundi, Aimen; Ibrahim, Mahmoud; Soliman, Mahmoud E S.

Metwally K; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia. kametwally@ut.edu.sa.
Abo-Dya NE; Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt. kametwally@ut.edu.sa.
Hamdan AME; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia.
Alrashidi MN; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
Alturki MS; Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia.
Aly OM; Pharm D Program, Faculty of Pharmacy, University of Tabuk, Tabuk, 71491, Saudi Arabia.
Aljoundi A; Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, 34212, Saudi Arabia.
Ibrahim M; Medicinal Chemistry Department Faculty of Pharmacy Port Said University, Port Said, 42526, Egypt.
Soliman MES; Molecular Bio-computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4001, South Africa.

Cell Biochem Biophys ; 81(4): 697-706, 2023 Dec.

Article en En | MEDLINE | ID: mdl-37658974

Asunto(s)

COVID-19; SARS-CoV-2; Humanos; ARN Viral; ARN Polimerasa Dependiente del ARN/química; ARN Polimerasa Dependiente del ARN/genética; ARN Polimerasa Dependiente del ARN/metabolismo; Suramina/farmacología; Antivirales/química; Simulación del Acoplamiento Molecular

Palabras clave

Cooperative drug binding; Molecular dynamics; RNA-dependent RNA polymerase (RdRp); SARS-CoV-2

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article