Integrated analysis of the ubiquitination mechanism reveals the specific signatures of tissue and cancer.
BMC Genomics
; 24(1): 523, 2023 Sep 04.
Article
en En
| MEDLINE
| ID: mdl-37667177
ABSTRACT
BACKGROUND:
Ubiquitination controls almost all cellular processes. The dysregulation of ubiquitination signals is closely associated with the initiation and progression of multiple diseases. However, there is little comprehensive research on the interaction and potential function of ubiquitination regulators (UBRs) in spermatogenesis and cancer.METHODS:
We systematically characterized the mRNA and protein expression of UBRs across tissues and further evaluated their roles in testicular development and spermatogenesis. Subsequently, we explored the genetic alterations, expression perturbations, cancer hallmark-related pathways, and clinical relevance of UBRs in pan-cancer.RESULTS:
This work reveals heterogeneity in the expression patterns of UBRs across tissues, and the expression pattern in testis is the most distinct. UBRs are dynamically expressed during testis development, which are critical for normal spermatogenesis. Furthermore, UBRs have widespread genetic alterations and expression perturbations in pan-cancer. The expression of 79 UBRs was identified to be closely correlated with the activity of 32 cancer hallmark-related pathways, and ten hub genes were screened for further clinical relevance analysis by a network-based method. More than 90% of UBRs can affect the survival of cancer patients, and hub genes have an excellent prognostic classification for specific cancer types.CONCLUSIONS:
Our study provides a comprehensive analysis of UBRs in spermatogenesis and pan-cancer, which can build a foundation for understanding male infertility and developing cancer drugs in the aspect of ubiquitination.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infertilidad Masculina
/
Neoplasias
Límite:
Humans
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Male
Idioma:
En
Año:
2023
Tipo del documento:
Article