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Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR.
Burger, Wessel A C; Pham, Vi; Vuckovic, Ziva; Powers, Alexander S; Mobbs, Jesse I; Laloudakis, Yianni; Glukhova, Alisa; Wootten, Denise; Tobin, Andrew B; Sexton, Patrick M; Paul, Steven M; Felder, Christian C; Danev, Radostin; Dror, Ron O; Christopoulos, Arthur; Valant, Celine; Thal, David M.
  • Burger WAC; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Pham V; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Vuckovic Z; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Powers AS; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Mobbs JI; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
  • Laloudakis Y; Departments of Computer Science, Structural Biology, and Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305, USA.
  • Glukhova A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Wootten D; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Tobin AB; Department of Chemistry, Stanford University, Stanford, CA, 94305, USA.
  • Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Paul SM; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Felder CC; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Danev R; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Dror RO; The Advanced Research Centre (ARC), Centre for Translational Science, School of Biomolecular Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
  • Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Valant C; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia.
  • Thal DM; Karuna Therapeutics, Boston, MA, 02110, USA.
Nat Commun ; 14(1): 5440, 2023 09 06.
Article en En | MEDLINE | ID: mdl-37673901
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Conducta Adictiva Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Conducta Adictiva Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article