Relaxivity Enhancement of Hybrid Micelles via Modulation of Water Coordination Numbers for Magnetic Resonance Lymphography.

Jiang, Yuting; Cai, Zhongyuan; Fu, Shengxiang; Gu, Haojie; Fu, Xiaomin; Zhu, Jiang; Ke, Yubin; Jiang, Hanqiu; Cao, Weidong; Wu, Changqiang; Xia, Chunchao; Lui, Su; Song, Bin; Gong, Qiyong; Ai, Hua

Jiang, Yuting; Cai, Zhongyuan; Fu, Shengxiang; Gu, Haojie; Fu, Xiaomin; Zhu, Jiang; Ke, Yubin; Jiang, Hanqiu; Cao, Weidong; Wu, Changqiang; Xia, Chunchao; Lui, Su; Song, Bin; Gong, Qiyong; Ai, Hua.

Jiang Y; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Cai Z; College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.
Fu S; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Gu H; College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.
Fu X; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Zhu J; College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.
Ke Y; Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Jiang H; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Cao W; College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.
Wu C; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610065, China.
Xia C; College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.
Lui S; Medical Imaging Key Laboratory of Sichuan Province and School of Medical Imaging, North Sichuan Medical College, Nanchong 637000, China.
Song B; Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China.
Gong Q; Spallation Neutron Source Science Center, Dongguan 523803, China.
Ai H; Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China.

Nano Lett ; 23(18): 8505-8514, 2023 09 27.

Article en En | MEDLINE | ID: mdl-37695636

ABSTRACT

ABSTRACT

Considerable efforts have been made to develop nanoparticle-based magnetic resonance contrast agents (CAs) with high relaxivity. The prolonged rotational correlation time (τR) induced relaxivity enhancement is commonly recognized, while the effect of the water coordination numbers (q) on the relaxivity of nanoparticle-based CAs gets less attention. Herein, we first investigated the relationship between T1 relaxivity (r1) and q in manganese-based hybrid micellar CAs and proposed a strategy to enhance the relaxivity by increasing q. Hybrid micelles with different ratios of amphiphilic manganese complex (MnL) and DSPE-PEG2000 were prepared, whose q values were evaluated by Oxygen-17-NMR spectroscopy. Micelles with lower manganese doping density exhibit increased q and enhanced relaxivity, corroborating the conception. In vivo sentinel lymph node (SLN) imaging demonstrates that DSPE-PEG/MnL micelles could differentiate metastatic SLN from inflammatory LN. Our strategy makes it feasible for relaxivity enhancement by modulating q, providing new approaches for the structural design of high-performance hybrid micellar CAs.

Asunto(s)

Micelas; Agua; Manganeso/química; Linfografía; Imagen por Resonancia Magnética/métodos; Espectroscopía de Resonancia Magnética; Medios de Contraste/química

Palabras clave

doping density; magnetic resonance imaging; manganese-based contrast agents; sentinel lymph node; the water coordination numbers

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