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Dinaciclib synergizes with BH3 mimetics targeting BCL-2 and BCL-XL in multiple myeloma cell lines partially dependent on MCL-1 and in plasma cells from patients.
Beltrán-Visiedo, Manuel; Jiménez-Alduán, Nelia; Díez, Rosana; Cuenca, Marta; Benedi, Andrea; Serrano-Del Valle, Alfonso; Azaceta, Gemma; Palomera, Luis; Peperzak, Victor; Anel, Alberto; Naval, Javier; Marzo, Isabel.
  • Beltrán-Visiedo M; Apoptosis, Immunity & Cancer Group, IIS Aragón, University of Zaragoza, Spain.
  • Jiménez-Alduán N; Apoptosis, Immunity & Cancer Group, IIS Aragón, University of Zaragoza, Spain.
  • Díez R; Apoptosis, Immunity & Cancer Group, IIS Aragón, University of Zaragoza, Spain.
  • Cuenca M; Hematology Service, Hospital Universitario Miguel Servet, Zaragoza, Spain.
  • Benedi A; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, The Netherlands.
  • Serrano-Del Valle A; Apoptosis, Immunity & Cancer Group, IIS Aragón, University of Zaragoza, Spain.
  • Azaceta G; Apoptosis, Immunity & Cancer Group, IIS Aragón, University of Zaragoza, Spain.
  • Palomera L; Hematology Service, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
  • Peperzak V; HCU-Lozano Blesa-Hematology Research Group, IIS Aragón, Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain.
  • Anel A; Hematology Service, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
  • Naval J; HCU-Lozano Blesa-Hematology Research Group, IIS Aragón, Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain.
  • Marzo I; Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, The Netherlands.
Mol Oncol ; 17(12): 2507-2525, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37704591
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Mieloma Múltiple / Antineoplásicos Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Mieloma Múltiple / Antineoplásicos Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article