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The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2.
Huang, Ruiqi; Warner Jenkins, Gabrielle; Kim, Yunjeong; Stanfield, Robyn L; Singh, Amrinder; Martinez-Yamout, Maria; Kroon, Gerard J; Torres, Jonathan L; Jackson, Abigail M; Kelley, Abigail; Shaabani, Namir; Zeng, Baisen; Bacica, Michael; Chen, Wen; Warner, Christopher; Radoicic, Jasmina; Joh, Joongho; Dinali Perera, Krishani; Sang, Huldah; Kim, Tae; Yao, Jianxiu; Zhao, Fangzhu; Sok, Devin; Burton, Dennis R; Allen, Jeff; Harriman, William; Mwangi, Waithaka; Chung, Donghoon; Teijaro, John R; Ward, Andrew B; Dyson, H Jane; Wright, Peter E; Wilson, Ian A; Chang, Kyeong-Ok; McGregor, Duncan; Smider, Vaughn V.
  • Huang R; Applied Biomedical Science Institute, San Diego, CA 92127.
  • Warner Jenkins G; Applied Biomedical Science Institute, San Diego, CA 92127.
  • Kim Y; College of Veterinary Medicine, Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506.
  • Stanfield RL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Singh A; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Martinez-Yamout M; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Kroon GJ; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Jackson AM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Kelley A; Applied Biomedical Science Institute, San Diego, CA 92127.
  • Shaabani N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.
  • Zeng B; OmniAb Inc., Emeryville, CA 94608.
  • Bacica M; Ligand Pharmaceuticals, San Diego, CA 92121.
  • Chen W; Ligand Pharmaceuticals, San Diego, CA 92121.
  • Warner C; Ligand Pharmaceuticals, San Diego, CA 92121.
  • Radoicic J; Ligand Pharmaceuticals, San Diego, CA 92121.
  • Joh J; School of Medicine, Department of Medicine, University of Louisville, Louisville, KY 40202.
  • Dinali Perera K; College of Veterinary Medicine, Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506.
  • Sang H; College of Veterinary Medicine, Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506.
  • Kim T; College of Veterinary Medicine, Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506.
  • Yao J; College of Veterinary Medicine, Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506.
  • Zhao F; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.
  • Sok D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.
  • Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.
  • Allen J; Ligand Pharmaceuticals, San Diego, CA 92121.
  • Harriman W; OmniAb Inc., Emeryville, CA 94608.
  • Mwangi W; College of Veterinary Medicine, Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506.
  • Chung D; School of Medicine, Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202.
  • Teijaro JR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.
  • Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Dyson HJ; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Wright PE; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Wilson IA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Chang KO; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • McGregor D; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037.
  • Smider VV; College of Veterinary Medicine, Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506.
Proc Natl Acad Sci U S A ; 120(39): e2303455120, 2023 09 26.
Article en En | MEDLINE | ID: mdl-37722054
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: SARS-CoV-2 / COVID-19 Límite: Animals Idioma: En Año: 2023 Tipo del documento: Article