Your browser doesn't support javascript.
loading
Lymph node dendritic cells harbor inducible replication-competent HIV despite years of suppressive ART.
Banga, Riddhima; Procopio, Francesco Andrea; Lana, Erica; Gladkov, Gregory T; Roseto, Isabelle; Parsons, Elizabeth M; Lian, Xiaodong; Armani-Tourret, Marie; Bellefroid, Maxime; Gao, Ce; Kauzlaric, Annamaria; Foglierini, Mathilde; Alfageme-Abello, Oscar; Sluka, Susanna H M; Munoz, Olivia; Mastrangelo, Andrea; Fenwick, Craig; Muller, Yannick; Mkindi, Catherine Gerald; Daubenberger, Claudia; Cavassini, Matthias; Trunfio, Rafael; Déglise, Sébastien; Corpataux, Jean-Marc; Delorenzi, Mauro; Lichterfeld, Mathias; Pantaleo, Giuseppe; Perreau, Matthieu.
  • Banga R; Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Procopio FA; Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Lana E; Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Gladkov GT; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Roseto I; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Parsons EM; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
  • Lian X; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
  • Armani-Tourret M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Bellefroid M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Gao C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Kauzlaric A; Translational Bioinformatics and Statistics Department of Oncology, University of Lausanne Swiss Cancer Center, Lausanne, Switzerland.
  • Foglierini M; Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Alfageme-Abello O; Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Sluka SHM; Newborn Screening Switzerland, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Munoz O; Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Mastrangelo A; Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Fenwick C; Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Muller Y; Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Mkindi CG; Ifakara Health Institute, Bagamoyo, United Republic of Tanzania; Department of Medical Parasitology and Infection Biology, Clinical Immunology Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Daubenberger C; Department of Medical Parasitology and Infection Biology, Clinical Immunology Unit, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, 4001 Basel, Switzerland.
  • Cavassini M; Services of Infectious Diseases, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Trunfio R; Services of Vascular Surgery, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Déglise S; Services of Vascular Surgery, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Corpataux JM; Services of Vascular Surgery, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Delorenzi M; Translational Bioinformatics and Statistics Department of Oncology, University of Lausanne Swiss Cancer Center, Lausanne, Switzerland.
  • Lichterfeld M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA.
  • Pantaleo G; Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland; Swiss Vaccine Research Institute, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
  • Perreau M; Services of Immunology and Allergy, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland. Electronic address: matthieu.perreau@chuv.ch.
Cell Host Microbe ; 31(10): 1714-1731.e9, 2023 10 11.
Article en En | MEDLINE | ID: mdl-37751747
ABSTRACT
Although gut and lymph node (LN) memory CD4 T cells represent major HIV and simian immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) in HIV persistence has long been limited to the blood due to difficulties to access lymphoid tissue samples. In this study, we show that LN migratory and resident DC subpopulations harbor distinct phenotypic and transcriptomic profiles. Interestingly, both LN DC subpopulations contain HIV intact provirus and inducible replication-competent HIV despite the expression of the antiviral restriction factor SAMHD1. Notably, LN DC subpopulations isolated from HIV-infected individuals treated for up to 14 years are transcriptionally silent but harbor replication-competent virus that can be induced upon TLR7/8 stimulation. Taken together, these results uncover a potential important contribution of LN DCs to HIV infection in the presence of ART.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Síndrome de Inmunodeficiencia Adquirida del Simio / Virus de la Inmunodeficiencia de los Simios Límite: Animals / Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / Síndrome de Inmunodeficiencia Adquirida del Simio / Virus de la Inmunodeficiencia de los Simios Límite: Animals / Humans Idioma: En Año: 2023 Tipo del documento: Article