A Novel ß-Globin Variant, Hb Raklev [ß 75(E19) HBB:c.227T > A (LeuâGln)].
Hemoglobin
; 47(4): 140-144, 2023 Nov.
Article
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| MEDLINE
| ID: mdl-37752804
ABSTRACT
We present a new hemoglobin variant, Hb Raklev, characterized by the substitution of leucine with glutamine at position 75 in the ß-globin chain. This variant was discovered inadvertently during an HbA1c evaluation using high performance liquid chromatography in a symptomless 54-year-old Caucasian woman, with the same variant also identified in her 16-year-old daughter. Purification of the hemoglobin revealed possibly diminished 2,3-bisphosphoglycerate (2,3-BPG) sensitivity, which may result in heightened oxygen affinity. Notably, two variants have been previously documented at this location the unstable Hb Atlanta and the high-affinity Hb Pasadena.
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Banco de datos:
MEDLINE
Asunto principal:
Hemoglobinas Anormales
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Globinas beta
Límite:
Adolescent
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Female
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Humans
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Middle aged
Idioma:
En
Año:
2023
Tipo del documento:
Article