Your browser doesn't support javascript.
loading
Early Phase Persistent Changes in the White Blood Cell Fraction in Patients With Advanced Urothelial Carcinoma Treated With Pembrolizumab: A Multicenter Retrospective Study.
Furubayashi, Nobuki; Minato, Akinori; Negishi, Takahito; Sakamoto, Naotaka; Song, Yoohyun; Hori, Yoshifumi; Tomoda, Toshihisa; Masaoka, Hiroyuki; Harada, Mirii; Tamura, Shingo; Kobayashi, Hiroki; Morihara, Kaede; Kuroiwa, Kentaro; Seki, Narihito; Fujimoto, Naohiro; Nakamura, Motonobu.
  • Furubayashi N; Department of Urology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan; nobumduro@gmail.com.
  • Minato A; Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Negishi T; Department of Urology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
  • Sakamoto N; Department of Urology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
  • Song Y; Department of Urology, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan.
  • Hori Y; Department of Urology, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
  • Tomoda T; Department of Urology, Oita Prefectural Hospital, Oita, Japan.
  • Masaoka H; Department of Urology, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan.
  • Harada M; Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Tamura S; Department of Medical Oncology, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
  • Kobayashi H; Department of Urology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
  • Morihara K; Department of Urology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
  • Kuroiwa K; Department of Urology, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
  • Seki N; Department of Urology, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan.
  • Fujimoto N; Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
  • Nakamura M; Department of Urology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
Anticancer Res ; 43(10): 4701-4708, 2023 Oct.
Article en En | MEDLINE | ID: mdl-37772560
ABSTRACT
BACKGROUND/

AIM:

The association of clinical outcomes with posttreatment persistent changes in eosinophils and other white blood cell (WBC) subtypes in patients with advanced urothelial cancer (UC) treated with pembrolizumab after the failure of platinum-based chemotherapy is unclear. PATIENTS AND

METHODS:

We retrospectively analyzed 87 patients with advanced UC who received pembrolizumab after the failure of platinum-based chemotherapy. The changes in WBC subtypes from pretreatment were evaluated three and six weeks after pembrolizumab administration. The association between the changes in the WBC subtypes and clinical outcomes was then evaluated using the Kaplan-Meier method and a Cox regression model.

RESULTS:

Among WBC subtypes, significant changes in the absolute (AEC) and relative eosinophil count (REC) and the neutrophil-to-eosinophil ratio (NER) were observed at three and six weeks compared with pretreatment (p<0.001). Multivariable Cox regression analyses revealed that a persistent decrease in AEC and REC and a persistent increase in NER were associated with poor overall survival.

CONCLUSION:

Persistent increase in AEC and REC and decrease in NER in the early phase after pembrolizumab may be significant early predictive markers of improved clinical outcomes in patients with advanced UC receiving pembrolizumab.
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Año: 2023 Tipo del documento: Article