NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1&#945; degradation via SIRT1 inhibition.

Joo, Hyun-Yoo; Jung, Jin Kyu; Kim, Mi-Yeon; Woo, Seon Rang; Jeong, Jae Min; Park, Eun-Ran; Kim, Yong-Min; Park, Joong-Jean; Kim, Joon; Yun, Miyong; Shin, Hyun-Jin; Lee, Kee-Ho

NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition.

Joo, Hyun-Yoo; Jung, Jin Kyu; Kim, Mi-Yeon; Woo, Seon Rang; Jeong, Jae Min; Park, Eun-Ran; Kim, Yong-Min; Park, Joong-Jean; Kim, Joon; Yun, Miyong; Shin, Hyun-Jin; Lee, Kee-Ho.

Joo HY; Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
Jung JK; Lab. of Biochemistry, School of Life Sciences & Biotechnology, Korea University, Seoul, Korea.
Kim MY; Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
Woo SR; Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
Jeong JM; Neuro-Oncology Branch, The Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Park ER; Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
Kim YM; Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
Park JJ; Department of Otolaryngology-Head and Neck Surgery, Kyung Hee University School of Medicine, Hyung Hee University Medical Center, Seoul, Republic of Korea.
Kim J; Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
Yun M; Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
Shin HJ; Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
Lee KH; Department of Physiology, College of Medicine, Korea University, Seoul, Korea.