Acute liver failure due to hepatitis A virus presented with Guillain-Barré syndrome and ocular myasthenia gravis.
BMJ Case Rep
; 16(10)2023 Oct 09.
Article
en En
| MEDLINE
| ID: mdl-37813556
ABSTRACT
Hepatitis A is one of the most common causes of acute viral hepatitis in children. Immunological manifestations involving the nervous system are rare with hepatitis A infection. We report a case of a toddler who presented with acute liver failure secondary to hepatitis A infection. The child showed clinical and laboratory improvement initially with conservative management. However, after the initial improvement, she developed acute-onset ptosis along with areflexia. Serological and neurophysiological tests revealed the occurrence of ocular variant Guillain-Barré syndrome and ocular myasthenia gravis, which was only partially responsive to treatment (intravenous immunoglobulin and pyridostigmine). A sudden clinical deterioration was noted after the onset of ptosis. She succumbed on day 40 of hospitalisation due to hospital-acquired infection along with the primary hepatic pathology. This is a rare coincidental presentation of acute viral hepatitis A infection with autoimmune manifestations.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Blefaroptosis
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Fallo Hepático Agudo
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Síndrome de Guillain-Barré
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Virus de la Hepatitis A
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Hepatitis A
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Miastenia Gravis
Límite:
Female
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Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article