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Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation.
Robin, Adrien; Van Ombergen, Angelique; Laurens, Claire; Bergouignan, Audrey; Vico, Laurence; Linossier, Marie-Thérèse; Pavy-Le Traon, Anne; Kermorgant, Marc; Chopard, Angèle; Py, Guillaume; Green, David Andrew; Tipton, Michael; Choukér, Alexander; Denise, Pierre; Normand, Hervé; Blanc, Stéphane; Simon, Chantal; Rosnet, Elisabeth; Larcher, Françoise; Fernandez, Peter; de Glisezinski, Isabelle; Larrouy, Dominique; Harant-Farrugia, Isabelle; Antunes, Inês; Gauquelin-Koch, Guillemette; Bareille, Marie-Pierre; Billette De Villemeur, Rebecca; Custaud, Marc-Antoine; Navasiolava, Nastassia.
  • Robin A; Univ Angers, CRC, CHU Angers, Inserm, CNRS, MITOVASC, Equipe CARME, SFR ICAT, F-49000, Angers, France. adrirobin@etud.univ-angers.fr.
  • Van Ombergen A; European Space Agency (ESA), Noordwijk, The Netherlands.
  • Laurens C; Institute of Metabolic and Cardiovascular Diseases, INSERM, Paul Sabatier University, UMR1297, Toulouse, France.
  • Bergouignan A; Anschutz Health and Wellness Center, Division of Endocrinology, University of Colorado, Aurora, CO, USA.
  • Vico L; INSERM, University Jean Monnet, Mines Saint-Etienne, U 1059, Saint Etienne, France.
  • Linossier MT; INSERM, University Jean Monnet, Mines Saint-Etienne, U 1059, Saint Etienne, France.
  • Pavy-Le Traon A; Department of Neurology, CHU Toulouse and I2MC-INSERM 1297, Toulouse, France.
  • Kermorgant M; Department of Neurology, CHU Toulouse and I2MC-INSERM 1297, Toulouse, France.
  • Chopard A; DMEM, Montpellier University, INRAE, Montpellier, France.
  • Py G; DMEM, Montpellier University, INRAE, Montpellier, France.
  • Green DA; Centre of Human and Applied Physiological Sciences, King's College London, London, UK.
  • Tipton M; Extreme Environments Laboratory, School of Sport, Health and Exercise Science, University of Portsmouth, Portsmouth, PO1 2EF, UK.
  • Choukér A; Laboratory of Translational Research Stress and Immunity, Department of Anesthesiology, Hospital of the Ludwig-Maximilians-University (LUM), Munich, Germany.
  • Denise P; Université de Caen Normandie, Inserm, COMETE U1075, CYCERON, CHU de Caen, F-14000, Caen, France.
  • Normand H; Université de Caen Normandie, Inserm, COMETE U1075, CYCERON, CHU de Caen, F-14000, Caen, France.
  • Blanc S; DEPE-IPHC - Département Ecologie, Physiologie et Ethologie, Strasbourg, France.
  • Simon C; CarMeN Laboratory, INSERM 1060, INRA 1397, University Claude Bernard Lyon1, Human Nutrition Research Center Rhône-Alpes, Oullins, France.
  • Rosnet E; Faculty of Sport Sciences, Université de Reims Champagne-Ardenne, Reims, France.
  • Larcher F; Laboratoire de Biochimie, CHU d'Angers, Angers, France.
  • Fernandez P; INSERM, University Jean Monnet, Mines Saint-Etienne, U 1059, Saint Etienne, France.
  • de Glisezinski I; Institute of Metabolic and Cardiovascular Diseases, INSERM, Paul Sabatier University, UMR1297, Toulouse, France.
  • Larrouy D; Institute of Metabolic and Cardiovascular Diseases, INSERM, Paul Sabatier University, UMR1297, Toulouse, France.
  • Harant-Farrugia I; Institute of Metabolic and Cardiovascular Diseases, INSERM, Paul Sabatier University, UMR1297, Toulouse, France.
  • Antunes I; Telespazio Belgium S.R.L. for the European Space Agency, Noordwijk, The Netherlands.
  • Gauquelin-Koch G; Centre National d'Études Spatiales (CNES), Paris, France.
  • Bareille MP; Institute of Space Physiology and Medicine (MEDES), Toulouse, France.
  • Billette De Villemeur R; Institute of Space Physiology and Medicine (MEDES), Toulouse, France.
  • Custaud MA; Univ Angers, CRC, CHU Angers, Inserm, CNRS, MITOVASC, Equipe CARME, SFR ICAT, F-49000, Angers, France. macustaud@chu-angers.fr.
  • Navasiolava N; Univ Angers, CRC, CHU Angers, Inserm, CNRS, MITOVASC, Equipe CARME, SFR ICAT, F-49000, Angers, France. nastassia.navasiolava@chu-angers.fr.
Nat Commun ; 14(1): 6311, 2023 10 09.
Article en En | MEDLINE | ID: mdl-37813884
ABSTRACT
Astronauts in microgravity experience multi-system deconditioning, impacting their inflight efficiency and inducing dysfunctions upon return to Earth gravity. To fill the sex gap of knowledge in the health impact of spaceflights, we simulate microgravity with a 5-day dry immersion in 18 healthy women (ClinicalTrials.gov Identifier NCT05043974). Here we show that dry immersion rapidly induces a sedentarily-like metabolism shift mimicking the beginning of a metabolic syndrome with a drop in glucose tolerance, an increase in the atherogenic index of plasma, and an impaired lipid profile. Bone remodeling markers suggest a decreased bone formation coupled with an increased bone resorption. Fluid shifts and muscular unloading participate to a marked cardiovascular and sensorimotor deconditioning with decreased orthostatic tolerance, aerobic capacity, and postural balance. Collected datasets provide a comprehensive multi-systemic assessment of dry immersion effects in women and pave the way for future sex-based evaluations of countermeasures.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vuelo Espacial / Ingravidez Límite: Female / Humans Idioma: En Año: 2023 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vuelo Espacial / Ingravidez Límite: Female / Humans Idioma: En Año: 2023 Tipo del documento: Article