Urinary stem cell-derived exocrine circRNA ATG7 regulates the SOCS1/STAT3 signaling pathway through miR-4500, inhibits M1 macrophage polarization, and alleviates the progression of diabetes nephropathy.

Sun, Yang; Zhao, Yanhong; Lu, Yongxin; Li, Hongmei; Xiang, Jin; Yang, Dongmei; Wang, Jinrui; Gao, Xinglian; Wang, Yian

Sun, Yang; Zhao, Yanhong; Lu, Yongxin; Li, Hongmei; Xiang, Jin; Yang, Dongmei; Wang, Jinrui; Gao, Xinglian; Wang, Yian.

Sun Y; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Zhao Y; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Lu Y; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Li H; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Xiang J; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Yang D; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Wang J; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Gao X; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Wang Y; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China. wangyian@kmmu.edu.cn.

Int Urol Nephrol ; 56(4): 1449-1463, 2024 Apr.

Article en En | MEDLINE | ID: mdl-37815664

Asunto(s)

Diabetes Mellitus; Nefropatías Diabéticas; Exosomas; MicroARNs; Animales; Humanos; Ratas; Diabetes Mellitus/metabolismo; Nefropatías Diabéticas/metabolismo; Exosomas/metabolismo; Macrófagos; MicroARNs/genética; ARN Circular/genética; ARN Circular/metabolismo; ARN Circular/farmacología; Transducción de Señal; Factor de Transcripción STAT3; Células Madre/metabolismo; Proteína 1 Supresora de la Señalización de Citocinas/genética; Proteína 1 Supresora de la Señalización de Citocinas/metabolismo; Proteína 1 Supresora de la Señalización de Citocinas/farmacología

Palabras clave

CircRNA ATG7; Diabetes nephropathy; Macrophage; Urogenic stem cells; miR-4500

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: MicroARNs / Diabetes Mellitus / Nefropatías Diabéticas / Exosomas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2024 Tipo del documento: Article

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