Transcriptomic cytoarchitecture reveals principles of human neocortex organization.
Science
; 382(6667): eadf6812, 2023 10 13.
Article
en En
| MEDLINE
| ID: mdl-37824655
ABSTRACT
Variation in cytoarchitecture is the basis for the histological definition of cortical areas. We used single cell transcriptomics and performed cellular characterization of the human cortex to better understand cortical areal specialization. Single-nucleus RNA-sequencing of 8 areas spanning cortical structural variation showed a highly consistent cellular makeup for 24 cell subclasses. However, proportions of excitatory neuron subclasses varied substantially, likely reflecting differences in connectivity across primary sensorimotor and association cortices. Laminar organization of astrocytes and oligodendrocytes also differed across areas. Primary visual cortex showed characteristic organization with major changes in the excitatory to inhibitory neuron ratio, expansion of layer 4 excitatory neurons, and specialized inhibitory neurons. These results lay the groundwork for a refined cellular and molecular characterization of human cortical cytoarchitecture and areal specialization.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neocórtex
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article