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Fraxetin inhibits proliferation and induces apoptosis of bladder cancer through the Akt pathway in vitro and in vivo.
Weng, Mingfang; Deng, Zhen; Huang, Shuijing; Lin, Xiaowen; Xu, Na; Sun, Xinghui; Wu, Weizhen; Lu, Jun; Wang, Dong.
  • Weng M; Department of Urology, 900TH Hospital of Joint Logistics Support Force, Fujian Medical University, Fuzhou, China.
  • Deng Z; Department of Urology, 900TH Hospital of Joint Logistics Support Force, Fujian Medical University, Fuzhou, China.
  • Huang S; Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
  • Lin X; Department of Vascular Surgery, Fujian Provincial People's Hospital, Fuzhou, China.
  • Xu N; Department of Urology, 900TH Hospital of Joint Logistics Support Force, Fujian Medical University, Fuzhou, China.
  • Sun X; Department of Urology, 900TH Hospital of Joint Logistics Support Force, Fujian Medical University, Fuzhou, China.
  • Wu W; Department of Urology, 900TH Hospital of Joint Logistics Support Force, Fujian Medical University, Fuzhou, China.
  • Lu J; Fujian Provincial Key Laboratory of Transplant Biology, Dongfang Hospital (900TH Hospital of Joint Logistics Support Force), Xiamen University, Fuzhou, China.
  • Wang D; Department of Urology, 900TH Hospital of Joint Logistics Support Force, Fujian Medical University, Fuzhou, China.
J Biochem Mol Toxicol ; 38(1): e23556, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37867445
ABSTRACT
Fraxetin, a natural compound extracted from the Chinese herb Cortex Fraxini, is reported to boast extensive antitumor properties in various cancers. However, whether fraxetin exhibited an anticancer effect on bladder cancer remains unknown. In this study, cell counting kit-8 was utilized to detect cell viability. Flow cytometry analysis was performed for cell apoptosis analysis. Western blot analysis and real-time PCR were used to ascertain gene expression analysis. A mouse bladder cancer xenograft model was established and subjected to fraxetin treatment. Fraxetin reduced the viability of bladder cancer cells, induced apoptosis in vitro, and inhibited the growth of bladder cancer in vivo. Fraxetin inhibited the Akt pathway in J82 cells. In conclusion, the growth inhibitory properties of fraxetin against bladder cancer may be mediated via an Akt inhibitory effect and cell apoptosis promotion.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Cumarinas / Proteínas Proto-Oncogénicas c-akt Límite: Animals / Humans Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Cumarinas / Proteínas Proto-Oncogénicas c-akt Límite: Animals / Humans Idioma: En Año: 2024 Tipo del documento: Article