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The reference range of lamotrigine in the treatment of epilepsy in children: a systematic review.
Chen, Jingjing; Huang, Liang; Zeng, Linan; Jiang, Zhimei; Xiong, Meiping; Jia, Zhi-Jun; Cheng, Guo; Miao, Liyan; Zhao, Limei; Zhang, Lingli.
  • Chen J; Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Huang L; Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Zeng L; NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, China.
  • Jiang Z; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.
  • Xiong M; Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Jia ZJ; Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Cheng G; NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, China.
  • Miao L; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.
  • Zhao L; Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Zhang L; Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.
Eur J Clin Pharmacol ; 80(1): 1-10, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37906300
PURPOSE: This study intends to assess the reference range of lamotrigine concentration for treating childhood epilepsy. METHODS: PubMed, Ovid-Embase, The Cochrane Library, CNKI, WanFang data and VIP databases were searched from database inception to January 2022. RCT, cohort study, case-control study, cross-sectional study that estimated the reference range of lamotrigine for children epilepsy treatment were included. The data extracted included basic information, statistical methods, data type, and results of reference range. Descriptive analysis was performed for them. RESULTS: 8 studies were included and estimated the reference range, and all of them were calculated based on efficacy data and/or concentration data. Statistical methods including ROC curve, concentration-effect curve, mean ± standard deviation, 95% confidence interval and percentile interval were utilized. For lamotrigine monotherapy, the lower limits ranged from 2.06 mg/L to 3.99 mg/L, and the upper limits ranged from 8.43 mg/L to 9.08 mg/L, showing basic consistency. However, for lamotrigine concomitant with valproate, the lower limits ranged from 2.00 mg/L to 8.00 mg/L, and the upper limit was 11.50 mg/L, for lamotrigine concomitant with other antiepileptics, the lower limits ranged from 1.00 mg/L to 3.09 mg/L, and the upper limits varied from 5.90 mg/L to 16.24 mg/L, indicating inconsistency. CONCLUSION: Several studies have estimated the reference range of lamotrigine for childhood epilepsy, while controversy exist and no studies have determined the upper limit of the range based on safety data. To establish the optimal reference range, further high-quality studies are necessary that consider both efficacy and safety data.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Epilepsia / Anticonvulsivantes Tipo de estudio: Systematic_reviews Límite: Child / Humans Idioma: En Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Epilepsia / Anticonvulsivantes Tipo de estudio: Systematic_reviews Límite: Child / Humans Idioma: En Año: 2024 Tipo del documento: Article