Association of serum copper (Cu) with cardiovascular mortality and all-cause mortality in a general population: a prospective cohort study.
BMC Public Health
; 23(1): 2138, 2023 11 01.
Article
en En
| MEDLINE
| ID: mdl-37915007
ABSTRACT
BACKGROUND:
Copper (Cu) homeostasis and Cu-induced cell death are gaining recognition as crucial processes in the pathogenesis of cardiovascular disease (CVD). Circulating Cu associated with CVD and mortality is yet to be fully elucidated.OBJECTIVE:
This national prospective cohort study is to estimate relationship between serum Cu and the risk of CVD and all-cause mortality.METHODS:
This study included participants from the National Health and Nutrition Examination Survey 2011-2016. Weighted Cox proportional hazards regression analysis and exposure-response curves were applied.RESULTS:
This included 5,412 adults, representing 76,479,702 individuals. During a mean of 5.85 years of follow-up (31,653 person-years), 96 CVD and 356 all-cause mortality events occurred. Age and sex-adjusted survival curves showed that individuals with higher levels of serum Cu experienced increased CVD and all-cause death rates (tertiles, p < 0.05). Compared with the participant in tertile 1 of serum Cu (< 16.31 mol/L), those in tertile 3 (≥ 19.84 mol/L) were significantly associated with CVD mortality (HR 7.06, 95%CI 1.85,26.96), and all-cause mortality (HR 2.84, 95% CI 1.66,4.87). The dose-response curve indicated a linear relationship between serum Cu and CVD mortality (p -nonlinear = 0.48) and all-cause (p -nonlinear = 0.62). A meta-analysis included additional three prospective cohorts with 13,189 patients confirmed the association between higher serum Cu and CVD (HR 2.08, 95% CI 1.63,2.65) and all-cause mortality (HR 1.89, 95%CI 1.58,2.25).CONCLUSION:
The present study suggests excessive serum Cu concentrations are associated with the risk of CVD and all-cause mortality in American adults. Our findings and the causal relationships require further investigation.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
/
Cobre
Límite:
Adult
/
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article