Role of Small Dense Low-density Lipoprotein Cholesterol in Cardiovascular Events in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus Receiving Statin Treatment.
J Atheroscler Thromb
; 31(4): 478-500, 2024 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-37926523
ABSTRACT
AIM:
There is little information on the relationships of serum small dense low-density lipoprotein cholesterol (sdLDL-C) levels and serum triglyceride (TG) levels with cardiovascular events in patients with coronary artery disease (CAD) and type 2 diabetes mellitus (DM) who are receiving statins. The aim of this study was to evaluate the relationships of serum TG levels and sdLDL-C levels as residual risks for cardiovascular events in patients with CAD and type 2 DM who were being treated with statins.METHODS:
The subjects were divided into four groups based on TG levels and sdLDL-C levels sdLDL-C of ï¼40.0 mg/dL and TG of ï¼150 mg/dL, sdLDL-C of ≥ 40.0 mg/dL and TG of ï¼150 mg/dL, sdLDL-C of ï¼40.0 mg/dL and TG of ≥ 150 mg/dL, and sdLDL-C of ≥ 40.0 mg/dL and TG of ≥ 150 mg/dL. During a median follow-up period of 1419 days, cardiovascular events occurred in 34 patients.RESULTS:
The incidences of cardiovascular events were significantly higher in patients with sdLDL-C of ≥ 40.0 mg/dL and TG of ï¼150 mg/dL and in patients with sdLDL-C of ≥ 40.0 mg/dL and TG of ≥ 150 mg/dL, but not in patients with sdLDL-C of ï¼40.0 mg/dL and TG of ≥ 150 mg/dL, than in patients with sdLDL-C of ï¼40.0 mg/dL and TG of ï¼150 mg/dL.CONCLUSIONS:
Under the condition of treatment with statins, patients with CAD and type 2 DM who had sdLDL-C levels of ≥ 40.0 mg/dL had a high risk for cardiovascular events even though serum TG levels were controlled at ï¼150 mg/dL.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de la Arteria Coronaria
/
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Diabetes Mellitus Tipo 2
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article