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Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides.
Pandi, Amir; Adam, David; Zare, Amir; Trinh, Van Tuan; Schaefer, Stefan L; Burt, Marie; Klabunde, Björn; Bobkova, Elizaveta; Kushwaha, Manish; Foroughijabbari, Yeganeh; Braun, Peter; Spahn, Christoph; Preußer, Christian; Pogge von Strandmann, Elke; Bode, Helge B; von Buttlar, Heiner; Bertrams, Wilhelm; Jung, Anna Lena; Abendroth, Frank; Schmeck, Bernd; Hummer, Gerhard; Vázquez, Olalla; Erb, Tobias J.
  • Pandi A; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany. amir.pandi@mpi-marburg.mpg.de.
  • Adam D; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
  • Zare A; Bundeswehr Institute of Microbiology, Munich, Germany.
  • Trinh VT; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
  • Schaefer SL; Department of Chemistry, Philipps-University Marburg, Marburg, Germany.
  • Burt M; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
  • Klabunde B; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.
  • Bobkova E; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.
  • Kushwaha M; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
  • Foroughijabbari Y; Université Paris-Saclay, INRAe, AgroParisTech, Micalis Institute, Jouy-en-Josas, France.
  • Braun P; Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
  • Spahn C; Bundeswehr Institute of Microbiology, Munich, Germany.
  • Preußer C; German Center for Infection Research (DZIF), Munich, Germany.
  • Pogge von Strandmann E; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Immunology, Infection and Pandemic Research, Munich, Germany.
  • Bode HB; Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
  • von Buttlar H; Institute for Tumor Immunology, Center for Tumor Biology and Immunology, Philipps-University Marburg, Marburg, Germany.
  • Bertrams W; Core Facility Extracellular Vesicles, Center for Tumor Biology and Immunology, Philipps-University of Marburg, Marburg, Germany.
  • Jung AL; Institute for Tumor Immunology, Center for Tumor Biology and Immunology, Philipps-University Marburg, Marburg, Germany.
  • Abendroth F; Core Facility Extracellular Vesicles, Center for Tumor Biology and Immunology, Philipps-University of Marburg, Marburg, Germany.
  • Schmeck B; Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany.
  • Hummer G; Molecular Biotechnology, Department of Biosciences, Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Vázquez O; Department of Chemistry, Chemical Biology, Philipps-University Marburg, Marburg, Germany.
  • Erb TJ; Senckenberg Gesellschaft für Naturforschung, Frankfurt, Germany.
Nat Commun ; 14(1): 7197, 2023 11 08.
Article en En | MEDLINE | ID: mdl-37938588
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aprendizaje Profundo / Péptidos Antimicrobianos Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Aprendizaje Profundo / Péptidos Antimicrobianos Idioma: En Año: 2023 Tipo del documento: Article