Do elevated thyrotropin levels increase the risk of miscarriages: yes or no?
Eur J Contracept Reprod Health Care
; 29(1): 32-36, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-37965691
ABSTRACT
BACKGROUND:
To examine correlation between elevated levels of thyrotropin with the frequency of miscarriages.METHODS:
A cross-sectional study was conducted on the 380 respondents and it investigated TSH (thyrotropin), thyroid peroxidase antibody(anti-TPO) and free thyroxine (FT4) in pregnant women who had a miscarriage (N = 179) and pregnant women with normal pregnancies (N = 201).RESULTS:
The incidence of subclinical hypothyroidism in the miscarriages group was higher than in control group (61.4% vrs 15.79% (p < 0.001). In the miscarriages group with hypothyroidism (first trimester) mean value of TSH was significantly higher 4.31 ± 2.55 mIU/L compared to the control group 1.95 ± 0.86mIU/L (p < 0.001). Logistic multivariate regression revealed that TSH and body mass index (BMI) have a significant influence on the miscarriage; TSH level has a higher odds ratio (OR) 1.47 CI (95% 1.22-1.78) than BMI (OR) 1.14 CI (95% 1.06-1.23)) (p < 0.001). The combination of thyroid autoimmunity and TSH > 2.5mIU/L increase the risk of miscarriage (65.75%) compared to positive anti-TPO antibodies and TSH < 2.5mIU/L(14.15%)(p < 0.001).CONCLUSIONS:
Higher TSH levels correspond with obesity during early pregnancy and may be a sign of maternal thyroid dysfunction. Physiological thyroid function in the first trimester of pregnancy is important for perinatal outcome.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tirotropina
/
Aborto Espontáneo
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Hipotiroidismo
Límite:
Female
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Humans
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Pregnancy
Idioma:
En
Año:
2024
Tipo del documento:
Article