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Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities.
Krais, John J; Glass, David J; Chudoba, Ilse; Wang, Yifan; Feng, Wanjuan; Simpson, Dennis; Patel, Pooja; Liu, Zemin; Neumann-Domer, Ryan; Betsch, Robert G; Bernhardy, Andrea J; Bradbury, Alice M; Conger, Jason; Yueh, Wei-Ting; Nacson, Joseph; Pomerantz, Richard T; Gupta, Gaorav P; Testa, Joseph R; Johnson, Neil.
  • Krais JJ; Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA. krais@wustl.edu.
  • Glass DJ; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA. krais@wustl.edu.
  • Chudoba I; Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
  • Wang Y; Temple University, Lewis Katz School of Medicine, Philadelphia, PA, 19140, USA.
  • Feng W; MetaSystems Probes, GmbH, Industriestr, 68804, Altlussheim, Germany.
  • Simpson D; Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
  • Patel P; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA.
  • Liu Z; Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA.
  • Neumann-Domer R; Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
  • Betsch RG; Cytogenetics Laboratory, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
  • Bernhardy AJ; Cytogenetics Laboratory, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
  • Bradbury AM; Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
  • Conger J; Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
  • Yueh WT; Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
  • Nacson J; Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
  • Pomerantz RT; Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
  • Gupta GP; Nuclear Dynamics Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
  • Testa JR; Thomas Jefferson University, Sidney Kimmel Cancer Center, Department of Biochemistry and Molecular Biology, Philadelphia, PA, 19107, USA.
  • Johnson N; Cancer Control and Prevention Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
Nat Commun ; 14(1): 7714, 2023 Nov 24.
Article en En | MEDLINE | ID: mdl-38001070
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteína BRCA1 / Genes BRCA2 Límite: Animals / Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteína BRCA1 / Genes BRCA2 Límite: Animals / Humans Idioma: En Año: 2023 Tipo del documento: Article