Molecular modeling of apoE in complexes with Alzheimer's amyloid-ß fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids.

Lewkowicz, Emily; Nakamura, Mari N; Rynkiewicz, Michael J; Gursky, Olga

Lewkowicz, Emily; Nakamura, Mari N; Rynkiewicz, Michael J; Gursky, Olga.

Lewkowicz E; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, W302, 700 Albany Street, Boston, MA, 02118, USA.
Nakamura MN; Undergraduate program, Department of Chemistry and Biochemistry, Middlebury College, 14 Old Chapel Rd, Middlebury, VT, 05753, USA.
Rynkiewicz MJ; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, W302, 700 Albany Street, Boston, MA, 02118, USA.
Gursky O; Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, W302, 700 Albany Street, Boston, MA, 02118, USA. gursky@bu.edu.

Cell Mol Life Sci ; 80(12): 376, 2023 Nov 27.

Article en En | MEDLINE | ID: mdl-38010414

Asunto(s)

Enfermedad de Alzheimer; Péptidos beta-Amiloides; Apolipoproteínas E; Humanos; Enfermedad de Alzheimer/metabolismo; Amiloide/metabolismo; Péptidos beta-Amiloides/metabolismo; Apolipoproteínas/química; Apolipoproteínas/metabolismo; Apolipoproteínas E/metabolismo; Encéfalo/metabolismo; Microscopía por Crioelectrón; Simulación de Dinámica Molecular; Fragmentos de Péptidos/metabolismo

Palabras clave

Amphipathic apolipoprotein α-helices; Amyloid signature proteins; Atomic structures; Cryptic binding sites; Exposed hydrophobic surfaces; Fibril polymorphs

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Apolipoproteínas E / Péptidos beta-Amiloides / Enfermedad de Alzheimer Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article

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