Schisandrin B, a dual positive allosteric modulator of GABA<sub>A</sub> and glycine receptors, alleviates seizures in multiple mouse models.

Wu, Jun; Zhao, Miao; Jin, Yu-Chen; Li, Min; Yu, Ke-Xin; Yu, Hai-Bo

Schisandrin B, a dual positive allosteric modulator of GABA_A and glycine receptors, alleviates seizures in multiple mouse models.

Wu, Jun; Zhao, Miao; Jin, Yu-Chen; Li, Min; Yu, Ke-Xin; Yu, Hai-Bo.

Wu J; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Zhao M; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Jin YC; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Li M; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Yu KX; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Yu HB; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. haiboyu@imm.ac.cn.

Acta Pharmacol Sin ; 45(3): 465-479, 2024 Mar.

Article en En | MEDLINE | ID: mdl-38017298

Asunto(s)

Epilepsia; Lignanos; Compuestos Policíclicos; Receptores de Glicina; Ratones; Animales; Humanos; Pilocarpina/efectos adversos; Estricnina/farmacología; Estricnina/uso terapéutico; Convulsiones/inducido químicamente; Convulsiones/tratamiento farmacológico; Receptores de GABA-A; Glicina/farmacología; Hipnóticos y Sedantes; Ácido gamma-Aminobutírico; Ciclooctanos

Palabras clave

GABAA receptors; Schisandrin B; epilepsy; glycine receptors

Texto completo

Imprimir

XML

PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Compuestos Policíclicos / Receptores de Glicina / Lignanos / Epilepsia Límite: Animals / Humans Idioma: En Año: 2024 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Search on Google