Local manufacturing processes contribute to variability in human mesenchymal stromal cell expansion while growth media supplements contribute to variability in gene expression and cell function: a Biomedical Excellence for Safer Transfusion (BEST) collaborative study.

Shaz, Beth H; Schäfer, Richard; Fontaine, Magali J; Norris, Philip J; McKenna, David H; Jin, Ping; Reems, Jo-Anna; Stroncek, David; Tanashi, Minoko; Marks, Denese; Geng, Huimin; Pati, Shibani

Shaz, Beth H; Schäfer, Richard; Fontaine, Magali J; Norris, Philip J; McKenna, David H; Jin, Ping; Reems, Jo-Anna; Stroncek, David; Tanashi, Minoko; Marks, Denese; Geng, Huimin; Pati, Shibani.

Shaz BH; Department of Pathology, Duke University, Durham, North Carolina, USA. Electronic address: beth.shaz@duke.edu.
Schäfer R; Institute for Transfusion Medicine and Immunohaematology, German Red Cross Blood Donor Service Baden-Württemberg-Hessen gGmbH, Goethe University Hospital, Frankfurt am Main, Germany; Institute for Transfusion Medicine and Gene Therapy, Medical Center University of Freiburg, Freiburg, Germany.
Fontaine MJ; University of Maryland School of Medical Science, Baltimore, Maryland, USA.
Norris PJ; Vitalant Research Institute, San Francisco, California, USA; Department of Lab Medicine, University of California San Francisco, San Francisco, California, USA.
McKenna DH; Molecular and Cellular Therapeutics, University of Minnesota, Saint Paul, Minnesota, USA.
Jin P; Cell Processing Section, Department of Transfusion Medicine, Clinical Center; National Institutes of Health, Bethesda, Maryland, USA.
Reems JA; Cell Therapy and Regenerative Medicine Facility, University of Utah, Salt Lake City, Utah, USA.
Stroncek D; Cell Processing Section, Department of Transfusion Medicine, Clinical Center; National Institutes of Health, Bethesda, Maryland, USA.
Tanashi M; Japanese Red Cross Blood Service Headquarters, Tokyo, Japan.
Marks D; Research and Development, Australian Red Cross Lifeblood, Sydney, NSW, Australia.
Geng H; Molecular and Cellular Therapeutics, University of Minnesota, Saint Paul, Minnesota, USA.
Pati S; Molecular and Cellular Therapeutics, University of Minnesota, Saint Paul, Minnesota, USA.