Baseline characteristics associated with the incidence of intraocular inflammation after the intravitreous injection of brolucizumab.
Int Ophthalmol
; 43(12): 4701-4709, 2023 Dec.
Article
en En
| MEDLINE
| ID: mdl-38044420
ABSTRACT
PURPOSE:
To investigate baseline characteristics associated with the incidence of intraocular inflammation (IOI) after the intravitreal injection of brolucizumab (IVBr) for the treatment of neovascular age-related macular degeneration (nAMD).METHODS:
This retrospective study included 66 eyes of 62 consecutive patients with nAMD who received IVBr (18 eyes were treatment naïve and 48 eyes had switched from other anti-vascular endothelial growth factor [VEGF] therapy). Baseline clinical characteristics were compared in non-IOI and IOI groups.RESULTS:
Although a dry macula was achieved at a high rate even 6 months after IVBr, IOI occurred in 8 of 66 eyes (12.1%; all had switched therapy) during the study period. Baseline characteristics including age, sex, nAMD type, lens status, visual acuity, central macular thickness, and a history of diabetes did not differ between the groups. The number of previous anti-VEGF injections before IVBr was greater in the IOI group (P = 0.004), and the ratio of patients with a laser flare-cell photometry (LFCP) value over 15 photon count per millisecond (pc/ms) was higher in the IOI group (P = 0.017). Multivariate logistic regression analysis showed that a greater number of previous anti-VEGF injections (odds ratio [OR] 1.12, P = 0.006; area under the curve 0.82, cut-off score 14.0) and an LFCP value over 15 pc/ms (OR 81.6, P = 0.031) were significantly associated with the incidence of IOI after IVBr.CONCLUSION:
A number of previous anti-VEGF injections greater than 14 and an LFCP value more than 15 pc/ms might be useful predictors of the incidence of IOI after IVBr in eyes with nAMD.Palabras clave
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1
Banco de datos:
MEDLINE
Asunto principal:
Uveítis
/
Degeneración Macular Húmeda
/
Mácula Lútea
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article