Determination of Two Wound Healing Components in Streptocaulon juventas (Lour.) Merr.: Periplogenin and Digitoxigenin.
Chem Biodivers
; 21(1): e202301585, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-38061998
ABSTRACT
Streptocaulon juventas (Lour.) Merr. (SJ) is a herbal medicine can promote wound healing. Cardiac glycosides, especially periplogenin, digitoxigenin, and their glycosides were the main constituents of SJ. We aim to establish a method for the simultaneous determination of periplogenin and digitoxigenin in SJ and evaluate the wound healing activities of these two components. UPLC-QqQ-MS/MS was used for the determination of periplogenin and digitoxigenin. Meanwhile, rats were subjected to full-thickness skin resection on the back to investigate the wound healing effects of periplogenin and digitoxigenin. The content of periplogenin and digitoxigenin in 13 batches of SJ extracts ranged from 43.26 to 97.15â
µg/g and 18.04 to 55.55â
µg/g, respectively. Periplogenin and digitoxigenin significantly increased the rate of wound healing in rats, increased the content of hydroxyproline in wound tissue, and improved the pathological state of wound skin tissue.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Apocynaceae
/
Digitoxigenina
Límite:
Animals
Idioma:
En
Año:
2024
Tipo del documento:
Article