Thoracic SMARCA4-deficient undifferentiated tumor: current knowledge and future perspectives.
Jpn J Clin Oncol
; 54(3): 265-270, 2024 Mar 09.
Article
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| MEDLINE
| ID: mdl-38117955
ABSTRACT
Thoracic SMARCA4-deficient undifferentiated tumor is a newly recognized disease entity characterized as a high-grade malignant neoplasm with an undifferentiated or rhabdoid phenotype. The tumor was initially identified as a subtype of thoracic sarcoma with SMARCA4 loss, but further investigation resulted in its classification as a subtype of epithelial malignancies in the current World Health Organization classification. SMARCA4-deficient undifferentiated tumor is highly aggressive and has a poor prognosis. Because of its rarity, an optimal treatment strategy has not yet been identified. In this review, we summarize the literature on SMARCA4-deficient undifferentiated tumor in terms of its clinical characteristics, diagnosis, treatment strategy and future perspectives.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sarcoma
/
Neoplasias de los Tejidos Blandos
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Neoplasias Torácicas
Límite:
Humans
Idioma:
En
Año:
2024
Tipo del documento:
Article