Increasing the versatility of the biphenyl-fused-dioxacyclodecyne class of strained alkynes.
Org Biomol Chem
; 22(3): 590-605, 2024 Jan 17.
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| MEDLINE
| ID: mdl-38131271
ABSTRACT
Biphenyl-fused-dioxacyclodecynes are a promising class of strained alkyne for use in Cu-free 'click' reactions. In this paper, a series of functionalised derivatives of this class of reagent, containing fluorescent groups, are described. Studies aimed at understanding and increasing the reactivity of the alkynes are also presented, together with an investigation of the bioconjugation of the reagents with an azide-labelled protein.
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2024
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Article