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Extended Postexposure Protection Against Vaginal Simian/Human Immunodeficiency Virus Infection With Tenofovir Alafenamide Fumarate/Elvitegravir Inserts in Macaques.
Makarova, Natalia; Singletary, Tyana; Peet, M Melissa; Mitchell, James; Bachman, Shanon; Holder, Angela; Dinh, Chuong; Lipscomb, Jonathan; Agrahari, Vivek; Mendoza, Maria; Pan, Yi; Heneine, Walid; Clark, Meredith R; García-Lerma, J Gerardo; Doncel, Gustavo F; Smith, James M.
  • Makarova N; Laboratory Branch, Division of HIV Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Singletary T; Laboratory Branch, Division of HIV Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Peet MM; CONRAD, Eastern Virginia Medical School, Norfolk, Virginia.
  • Mitchell J; Laboratory Branch, Division of HIV Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Bachman S; Laboratory Branch, Division of HIV Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Holder A; Laboratory Branch, Division of HIV Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Dinh C; Laboratory Branch, Division of HIV Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Lipscomb J; Laboratory Branch, Division of HIV Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Agrahari V; CONRAD, Eastern Virginia Medical School, Norfolk, Virginia.
  • Mendoza M; Quantitative Sciences Branch, Division of HIV Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Pan Y; Quantitative Sciences Branch, Division of HIV Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Heneine W; Laboratory Branch, Division of HIV Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Clark MR; CONRAD, Eastern Virginia Medical School, Norfolk, Virginia.
  • García-Lerma JG; Laboratory Branch, Division of HIV Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Doncel GF; CONRAD, Eastern Virginia Medical School, Norfolk, Virginia.
  • Smith JM; Laboratory Branch, Division of HIV Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
J Infect Dis ; 229(6): 1791-1795, 2024 Jun 14.
Article en En | MEDLINE | ID: mdl-38134382
ABSTRACT
Vaginal inserts that can be used on demand before or after sex may be a desirable human immunodeficiency virus (HIV) prevention option for women. We recently showed that inserts containing tenofovir alafenamide fumarate (TAF, 20 mg) and elvitegravir (EVG, 16 mg) were highly protective against repeated simian/human immunodeficiency virus (SHIV) vaginal exposures when administered to macaques 4 hours before or after virus exposure (93% and 100%, respectively). Here, we show in the same macaque model that insert application 8 hours or 24 hours after exposure maintains high efficacy (94.4% and 77.2%, respectively). These data extend the protective window by TAF/EVG inserts and inform their clinical development for on-demand prophylaxis in women.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Adenina / Síndrome de Inmunodeficiencia Adquirida del Simio / Quinolonas / Fármacos Anti-VIH / Alanina / Tenofovir Límite: Animals Idioma: En Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Adenina / Síndrome de Inmunodeficiencia Adquirida del Simio / Quinolonas / Fármacos Anti-VIH / Alanina / Tenofovir Límite: Animals Idioma: En Año: 2024 Tipo del documento: Article